El 02 de Junio inicio la primera ronda de dobles femeninos en el Abierto de Francia 2021. Los resultados fueron los siguientes:
| Salma Djoubri – Océane Dodin | 2 | 3 |
| Amanda Anisimova – Anastasia Potapova | 6 | 6 |
| Margot Yerolymos – Diane Parry | 5 | 4 |
| Nicole Melichar – Demi Schuurs | 7 | 6 |
| Makoto Ninomiya – Yang Zhaoxuan | 6 | 6 |
| Sara Sorribes Tormo – Marie Bouzková | 2 | 2 |
| Shelby Rogers – Petra Marti? | 7 | 6 |
| Tímea Babos – Vera Zvonareva | 6 | 3 |
| Harmony Tan – Amandine Hesse | 3 | 2 |
| Katerina Siniaková – Barbora Krej?iková | 6 | 6 |
| Lauren Davis – Ankita Raina | 4 | 4 |
| Laura Siegemund – Lucie Hradecká | 6 | 6 |
| Kaitlyn Christian – Sabrina Santamaria | 3 | 5 |
| Varvara Gracheva – Zarina Diyas | 6 | 7 |
| Martina Trevisan – Aleksandra Kruni? | 0 | 1 |
| Karolína Plíšková – Kristyna Plíšková | 6 | 6 |
| Zhang Shuai – Xu Yifan | 6 | 6 |
| Viktorija Golubic – Alexandra Panova | 4 | 4 |
| Giuliana Olmos – Sharon Fichman | 6 | 6 |
| Anna Blinkova – Heather Watson | 3 | 2 |
| Arantxa Rus – Tamara Zidanšek | 6 | 6 |
| Rebecca Peterson – Cornelia Lister | 3 | 0 |
| Alexa Guarachi – Desirae Krawczyk | 3 | 7 | 3 |
| Magda Linette – Bernarda Pera | 6 | 6 | 6 |
| Chloé Paquet – Clara Burel | 6 | 6 |
| Renata Vorá?ová – Miyu Kato | 3 | 0 |
| Zheng Saisai – Ellen Perez | 6 | 6 | 6 |
| Coco Gauff – Venus Williams | 7 | 4 | 3 |
| Lyudmyla Kichenok – Arina Rodionova | 1 | 7 | 4 |
| Nadiia Kichenok – Raluca Olaru | 6 | 5 | 6 |
| Hsieh Su-wei – Elise Mertens | 6 | 6 |
| Elixane Lechemia – Elsa Jacquemot | 2 | 3 |
| Jasmine Paolini – Nina Stojanovi? | 2 | 6 | 3 |
| Jessica Pegula – Asia Muhammad | 6 | 2 | 6 |
| Alicja Rosolska – CoCo Vandeweghe | 6 | 3 | 2 |
| Andreea Mitu – Yulia Putintseva | 3 | 6 | 6 |
| Aubane Droguet – Selena Janicijevic | 0 | 1 |
| Bethanie Mattek-Sands – Iga ?wiatek | 6 | 6 |
| Vivian Heisen – Kveta Peschke | 6 | 3 | 7 |
| Astra Sharma – Hayley Carter | 3 | 6 | 5 |
